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Slade was the most high-profile omission as Eddie Jones named his 36-man squad to take on Japan, South Africa, New Zealand and Argentina in the Autumn Nations Series this November.
Other notable exclusions include Saracens centre Elliot Daly and veteran scrum-half Danny Care, whose international career looks to be over.
Care's club teammate Joe Marler, who played his 250th game for Harlequins on Sunday, also misses out despite Jones saying he was still available for selection last month.
There is a first call-up for Harlequins winger Cadan Murley, who took his Premiership try-scoring tally to seven in defeat to Leicester Tigers last weekend.
Hugh Tizard, David Ribbans, Val Rapava Ruskin, George McGuigan and Alex Coles are the other uncapped inclusions.
Elsewhere Val Rapava Ruskin, Raffi Quirke, Max Malins and Kyle Sinckler return after missing out on England's summer series win in Australia.
Ollie Lawrence's impressive start to the season with Worcester and Bath has not been rewarded with a place in Jones' autumn plans.
"This is a very strong, vibrant squad and a number of good players have been left out. We are pleased with the depth and the strength of the squad," said Jones.
"The autumn internationals will be like a mini Rugby World Cup for us, starting with two tough games against Argentina and Japan which mirrors our Pool fixtures at next year’s tournament.
"Then we’ll have knock out type games against New Zealand and South Africa – all four games will be great tests for us."
The 36-player squad will meet on Monday for a five-day training camp in Jersey before returning to Pennyhill Park ahead of their first game against Argentina on Sunday 6 November.
On the inclusion of uncapped winger Murley, Jones said: "I've been watching him quite closely. He's got the ability to finish. He's a good, strong player who has improved his capacity to win the ball in the air remarkably."
Meanwhile Jack Willis is the only player from financially-stricken Wasps and Worcester.
Worcester face relegation from the Premiership after entering administration and Wasps could meet the same fate unless they can find a solution to their financial woes.