Both sides have made a perfect start since the Premier League's return and neither team will want to give up their unbeaten record.
Hosts Chelsea are coming off the back of a come-from-behind win over struggling Aston Villa.
City, who have racked up eight goals in two games with eye-catching victories over Arsenal and Burnley, will be desperate to extend their winning sequence on Thursday night and prolong Liverpool's wait for a first top-flight title for 30 years.
The Citizens will officially relinquish their Premier League crown to Liverpool if Jurgen Klopp's side beat Crystal Palace on Wednesday and Guardiola's men fail to win at Stamdord Bridge a day later.
The visitors might also have to do without their club record goalscorer Sergio Aguero, who picked up a knee injury in City's 5-0 demolition of Sean Dyche's Clarets on Monday.
Aguero's likely absence will be a huge blow for Guardiola given the diminuative Argentian's record against Chelsea.
The man they call 'Kun' has scored 10 goals in his last nine appearances against Chelsea in all competitions, including two hat-tricks in that run.
Brazilian Gabriel Jesus is likely to deputise up front while Phil Foden could be rewarded for his recent form with a starting berth.
Will Lampard's Blues cement their hold on fourth place with a victory or will City continue their mesmeric form to delay Liverpool's first league title in 30 years?
When is Chelsea v Manchester City?
Our coverage gets underway at 7.30pm (8.15pm kick off) on Thursday 25 June, live on BT Sport 1 HD and BT Sport Ultimate on TV.
How to watch Chelsea v Manchester City on your mobile or tablet
Watch on the go with the BT Sport app with a link to the live stream available at the top of the homepage when our coverage gets underway.
With the enhanced video player featuring an interactive timeline, multi-camera functionality, 360° live streaming and highlights, the app truly offers the most-immersive viewing experience available.
How to live stream Chelsea v Manchester City on your laptop
Chelsea v Manchester City is available to live stream here!
Follow the link above or access the live stream via the bt.com/sport home page when our broadcast begins.
With access to in-game stats, real-time table changes and more, our matchday page will enhance your viewing ever further.
How to watch Chelsea v Manchester City on TV
Check out all the key info about the English top flight returning to BT Sport, including what games we're showing and how to watch them.
*BT Sport customers can download the BT Sport app on PS4, Xbox, Apple TV and Samsung Smart TVs (2015 models onwards). To watch the action, follow the link at the top of the homepage.
What if I can't watch live?
No problem. A highlights package of the clash will be made available to all shortly after the game on both the BT Sport app and bt.com/sport. We'll also publish in-game clips throughout the 90 minutes.
There will also be several opportunities to watch the match in full on TV and online after the event. For more information on the latest listings, check out our TV Guide.
What other live football does BT Sport show?
We're showing 20 live Premier League games before the end of the season, as well as all remaining Champions League and Europa League matches live.
For full details of BT Sport's upcoming live football schedule, check out our What's on BT Sport page.