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Read on for a preview of Hearts' trip to Fiorentina and West Ham's home match against Anderlecht, as well as how to watch any of Thursday’s other matches.
Fiorentina vs Hearts – 5.15pm (5.45pm kick-off) on BT Sport 3 – Live stream
This looks like an impossible task for Hearts, who lost 3-0 at home to the Italians last week.
In what was always going to be the Scottish side’s toughest fixture, they now need to win in Florence to have any hopes of extending their first European campaign in 18 years.
And they’ll have to pull something out of the bag without defender Lewis Neilson, who received a straight red card for his shirt pull on Luka Jovic at Tynecastle.
Looking at the positives, Jam Tarts’ manager Robbie Neilson might be able to welcome back defensive duo Andy Halliday and Michael Smith from injury.
Fiorentina were on a terrible run of form before their trip to Edinburgh, with just one win in 10 matches, plus they suffered a 4-0 defeat to Lazio at the weekend, so their confidence could be low.
French forward Jonathan Ikone is available for selection again after missing the reverse fixture through suspension. Plus, La Viola have proven goalscorer Luka Jovic up front, who's always capable of getting on the scoresheet despite only having two goals to his name so far this season.
West Ham vs Anderlecht – 7.45pm (8pm kick-off) on BT Sport 2 – Live stream
A win for West Ham against Anderlecht would see them finish as Group B champions regardless of what happens in their final two fixtures. That would be welcome relief to Hammers’ manager David Moyes, who could then rest players and focus on domestic fixtures.
West Ham have a perfect record so far in the competition and beat Anderlecht in Belgium 1-0 last week.
Summer signing Gianluca Scamacca was preferred to Michail Antonio at the weekend, though the Jamaican international started in Anderlecht last week. West Ham face Southampton on Sunday, so it’s likely that both strikers will be given some game time regardless of who starts.
Lucas Pacqueta and Declan Rice were also rested last week, but with a win sealing the group for West Ham, Moyes may try and get the job done and dusted by fielding a strong team in front of the home fans.
Jared Bowen could be rested and Maxwel Cornet is likely to miss out through injury, but youngster Flynn Downes could get more minutes after starting for only the second time this season in the reverse fixture.
Ex-Tottenham defender Jan Vertonghen looks set to miss out on a return to London through injury, but Wolves loanee Fabio Silva should start up front.
Thursday’s other Europa Conference League fixtures and how to watch them
Istanbul Basaksehir vs Rigas FS – 5.45pm KO, Live stream
Austria Wien vs Villarreal – 5.45pm KO, Live stream
Slovan Bratislava vs Basel – 5.45pm KO, Live stream
CFR Cluj vs Slavia Praha – 5.45pm KO, Live stream
Djurgarden vs Gent – 5.45pm KO, Live stream
Partizan vs Koln – 5.45pm KO, Live stream
Apollon vs AZ – 5.45pm KO, Live stream
Shamrock Rovers vs Molde – 7.45pm (8pm KO) on BT Sport 4 – Live stream
Hapoel Be’er Sheva vs Lech Poznan – 8pm KO, Live stream
Nice vs Slovacko – 8pm KO, Live stream
FCSB vs Silkeborg – 8pm KO, Live stream
Ballkani vs Sivasspor – 8pm KO, Live stream
Zalgiris vs Pyunik – 8pm KO, Live stream
Vaduz vs Dnipro-1 – 8pm KO, Live stream