UCL Magazine - Di Maria, Zubimendi and Buruk interviewsSep 29
The initial draw pitted Ralf Rangnick's side against Paris Saint-Germain but a technical error meant the ties had to be redrawn, with a slightly more favourable outcome for Man United.
Full Last 16 Draw
Benfica vs Ajax
Villarreal vs Juventus
RB Salzburg vs Bayern Munich
Inter Milan vs Liverpool
Sporting CP vs Manchester City
Chelsea vs Lille
Atletico Madrid vs Manchester United
Paris Saint-Germain vs Real Madrid
*Unseeded teams named first, will play at home in the first leg
The draw initially took place at 11am UK time at UEFA's headquarters in Nyon, but they were forced to declare it null and void after a series of mistakes in the process.
United were mistakenly paired with Villarreal, who they could not face due to both sides being in the same group.
It meant Atletico Madrid were left off the list of possible opponents to face The Red Devils and the Premier League side drew PSG.
A number of clubs, including Atletico, sought clarification and the draw was declared void and scheduled to be redone for 2pm UK time.
After drawing PSG in the initial event - in a renewal of the Lionel Messi and Cristiano Ronaldo rivalry - Man Utd will be relieved to have avoided the Parisien giants in the second draw.
Rangnick's men will however face the notoriously-difficult Atletico Madrid with Diego Simeone's men experts at negotiating two-legged knockout ties.
Liverpool, after taking on AC Milan in the group stages, take on their city rivals Inter for a place in the quarter-finals with a return to the San Siro for the first leg.
Jurgen Klopp's side were one of three teams to win all six of their group-stage matches, while Inter finished behind Real Madrid as runners-up in Group D.
Chelsea, who finished as an unseeded team after Juventus pipped them in Group H, avoided heavyweights PSG and Real Madrid by drawing Ligue 1 outfit Lille.
The Blues were paired against Lille in the initial draw too and face the French side who edged out a watertight Group G to finish top.
Man City, the bookmakers' favourites to win the competition, will fancy their chances of advancing past Portuguese giants Sporting CP after topping a group featuring PSG to qualify as a seeded side.
Guardiola's men were initially pitted against Villarreal but will now face Ruben Amorim's side - who finished in second place in Ajax's group.
The glamour tie of the round sees Carlo Ancelotti face off against his former club PSG, as Messi meets his former rivals Real Madrid over two legs.
Meanwhile Juventus, who finished above Chelsea, take on Unai Emery's Europa League winners Villarreal with the first leg at the coast of the Balearic Sea.
There's an intriguing clash between two former winners of the competition in Benfica and Ajax. The Dutch giants won all six of their matches in the group stages and meet a Benfica team who qualified ahead of Barcelona.
And the final tie sees German giants Bayern Munich face an RB Salzburg team who are competing in the Champions League knockout stages for the first time in their history.
Bayern were the top scorers in the group stages with 22, with only three conceded, and will fancy their chances of overcoming the Austrian newcomers.
What is the format for the Champions League last 16?
The teams that finished as runners-up will play at home first, with the first legs played on February 15/16/22/23. The return legs will be played on March 8/9/15/16.
What has changed in the 2021/22 Champions League knockouts?
The away goals rule has been scrapped. Ties level after 180 minutes will go to extra time regardless of the number of goals each team has scored home or away.
If the teams still cannot be separated after the additional 30 minutes of extra time, the tie will be decided via a penalty shootout.
What are the dates for the Champions League knockout stage games?
Round of 16 first legs: February 15/16/22/23
Round of 16 second legs: March 8/9/15/16
Quarter-finals first legs: April 5/6
Quarter-finals second legs: April 12/13
Semi-finals first legs: April 26/27
Semi-finals second legs: May 3/4
Final: May 28 at the Gazprom Arena in St Petersburg
When are the remaining draws taking place?
The quarter-final and semi-final draws will take place on Friday 18 March, 2021.